妊娠中的急性,慢性和妊娠特异性肝病的流行病学趋势
Gabrielle Jutras1, Cynthia Fenton2, Jennifer A Flemming3
1Division of Gastroenterology and Hepatology, Department of Medicine, UCSF.
The American journal of gastroenterology
|July 30, 2025
概括
妊娠期间的慢性肝病 (CLD) 正在增加,这是由代谢功能障碍相关的脂肪性肝病 (MASLD) 推动的. 孕期特异性肝脏疾病在CLD中更常见,突出显示了怀孕前护理的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 产科 产科 产科 产科 产科
- 流行病学 流行病学
背景情况:
- 生殖年龄的女性面临越来越多的慢性肝病 (CLD),特别是与酒精有关的 (ALD) 和与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 现有有限的当代数据存在于这种人口中的急性,慢性和怀孕特异性肝病.
研究的目的:
- 分析十多年来孕妇中急性,慢性和怀孕特异性肝病的趋势.
- 为了研究慢性肝病与妊娠特异性肝病之间的关联.
主要方法:
- 在高等中心进行了一项为期10年的回顾性研究 (2014-2023年),包括51,708例怀孕.
- 通过诊断代码识别肝脏疾病;从电子病历中收集数据.
- 统计分析包括千平方,学生的t测试,以及考克兰-阿米塔奇测试的时间趋势.
主要成果:
- 2.8%的怀孕 (1,429) 患有肝脏疾病:4.8%急性,51.8%的CLD (4.4%肝硬化) 和44.5%的怀孕特定.
- 怀孕期间的CLD增加了2.5倍,从病毒性肝炎明显转向MASLD (p<0.01).
- 孕期特异性肝病 (ICP,AFLP,HELLP,肝脏参与的孕前) 在患有CLD的女性中更为频繁 (p<0.01).
结论:
- 怀孕期间的CLD显著增加,主要是由于MASLD,在10年内观察到.
- 孕期特定的肝脏疾病在患有潜在的CLD的女性中更为普遍.
- 强调需要肝脏病学预孕咨询和早期产科合作,以改善孕产妇和胎儿的结果.
相关概念视频
01:26Diseases of the Liver and Gallbladder
1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K
01:24Chronic Pancreatitis I: Introduction
162
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
162
01:30Liver Physiology
1.3K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
1.3K
01:16Hepatic Drug Excretion: Influencing Factors
226
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
226
01:07Teratogenicity
2.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.8K
01:27Acute Pancreatitis I: Introduction
492
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
492