在黑色素瘤研究和常规实践中使用的患者报告的结果测量和验证数据:系统性审查
Jake R Thompson1,2, Tayla B McCutcheon1,2, Linda K Martin2,3
1Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
JAMA dermatology
|July 30, 2025
概括
患者报告的结果测量 (PROM) 在黑色素瘤研究中被广泛使用,但缺乏具体的验证. 这次审查发现很少有具有黑色素瘤特异数据的PROM,强调需要更多的研究来确保准确的患者结局评估.
科学领域:
- 在瘤学瘤学.
- 健康 结果 研究 研究 结果
- 心理测量 心理测量 心理测量
背景情况:
- 患者报告的结果测量 (PROM) 在黑色素瘤研究和临床决策中越来越重要.
- 然而,对于黑色素瘤患者群体,这些仪器的具体验证在很大程度上是未知的.
研究的目的:
- 系统地审查在黑色素瘤研究和临床实践中使用的PROM.
- 构建一个证据差距地图,识别这些PROMs的黑色素瘤特定验证数据.
主要方法:
- 在多个数据库 (MEDLINE,Embase,Web of Science等) 中进行全面的系统搜索. 是进行的.
- 包括从2010年1月1日起发表的使用PROM治疗黑色素瘤患者的研究.
- 数据提取集中在PROM使用,结果类别和可用的验证数据上.
主要成果:
- 分析了124项涉及32,784名参与者的研究,使用了110个独特的PROM.
- 最常见的结果类别是情绪/心理健康,与健康有关的生活质量和自我功能.
- 重要的是,只有17个PROM (15%) 拥有黑色素瘤特定的验证数据,只有一个调查问卷拥有完整的心理测量数据.
结论:
- 在黑色素瘤研究中使用PROM是高度异质的,显著缺乏黑色素瘤特定的验证.
- 这突显了在确保黑色素瘤护理中患者结果评估的可靠性和准确性的关键差距.
- 未来的研究必须优先考虑心理测量评估,以验证黑色素瘤人群中常用的PROM.
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