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Updated: Sep 13, 2025

Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay
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Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay

Published on: February 3, 2022

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S相检查点可以防止异常的复制分叉处理和降解

Iván Núñez-Martín1,2, Lucy S Drury3, María I Martínez-Jiménez4

  • 1Andalusian Center of Molecular Biology and Regenerative Medicine, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville 41092, Spain.

Nucleic acids research
|July 30, 2025
PubMed
概括

癌细胞中的复制压力由检查点来管理. 我们的研究表明,DNA处理因子会通过在停滞的分叉处降解新生的DNA导致细胞死亡,这是人类PrimPol.Pol可以预防的过程.

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