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Updated: Sep 13, 2025

Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication
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Published on: August 23, 2024

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基断裂诱导的复制的晚期阶段抑制了与BRCA1缺陷相关的并联重复

Zhi-Cheng Huang1,2,3, Yi-Li Feng1,2,3, Qian Liu1,3

  • 1Key Laboratory of Laparoscopic Technology of Zhejiang Province, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, 310016 Hangzhou, P. R. China.

Nucleic acids research
|July 30, 2025
PubMed
概括

在BRCA1缺乏的细胞中,微同质介导的协同重复 (TDs) 增加,这是由复制压力驱动的. 基断裂诱导复制 (aBIR) 和RAD51独立途径的晚期阶段有助于TD的形成.

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