主要甲状腺淋巴瘤的生存趋势和与生存相关的因素:基于SEER的分析 (1975-2021)
Freddy J K Toloza1, Sriram Gubbi1, Joanna Klubo-Gwiezdzinska1
1Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
概括
初级甲状腺淋巴瘤 (PTL) 的存活率有显著改善,特别是结合化疗和放射治疗. 影响生存的关键因素包括年龄,疾病阶段和这种罕见癌症的治疗方式.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 初级甲状腺淋巴瘤 (PTL) 是一种罕见的恶性瘤,占甲状腺癌的<5%和淋巴瘤的~2.5%.
- 从历史上看,通过手术和放射治疗的PTL治疗结果很差.
- 化学疗法和辐射联合疗法的近期进展改善了生存率,但长期趋势需要探索.
研究的目的:
- 描述PTL的临床和人口特征.
- 为了评估随着时间的推移PTL存活率的变化.
- 为了确定与PTL存活率独立相关的因素.
主要方法:
- 使用监测,流行病学和最终结果 (SEER) 数据 (1975-2021) 的回顾性队列研究.
- 分析患者人口统计,淋巴瘤亚型,阶段和治疗方式.
- 卡普兰-梅尔和考克斯对生存分析的比例危险模型.
主要成果:
- 总共有2465名PTL患者被分析;76%的患者在2000年后被诊断出来.
- 平均整体存活时间为150个月;1年,5年和10年的生存率为84.9%,72.9%和57.7%.
- 2000年后的生存率显著改善 (p<0.001). 年龄≥70岁,区域/远程转移与较差的疾病特异性存活率 (DSS) 有关. 结合化疗和放射治疗产生了最高的10年DSS (86.6%).
结论:
- 近几十年来,PTL存活率显著提高.
- 治疗的进步,特别是化学疗法和放射治疗的结合,是关键.
- 疾病表现的变化,包括早期诊断和阶段分布,也可能有所贡献.
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