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超声波矩阵成像用于体内3D跨部局部化显微镜

Flavien Bureau¹, Louise Denis², Antoine Coudert²

¹PSL University, ESPCI Paris, CNRS, Institut Langevin, Paris, France.

Science advances

|July 30, 2025

概括

超声波矩阵成像克服了头骨扭曲,增强了超分辨率大脑成像的微泡检测. 这种技术提供了一种非电离化方法来观察深层大脑的微血管,有助于中风研究.

科学领域:

医疗成像医学成像
生物医学工程生物医学工程
神经科学是一个神经科学.

背景情况:

超超声波成像面临的局限性是由于头骨诱导的信号减弱和偏差.
超声波定位显微镜 (ULM) 使用微泡和超快技术实现微米级脑血管成像.
在ULM中波面扭曲会降低微气泡检测和定位准确度.

研究的目的:

为了解决波面扭曲限制超声本地化显微镜 (ULM) 的问题,用于跨脑成像.
引入和验证超声波矩阵成像作为改善ULM性能的解决方案.
为了证明深层大脑微血管的增强体内成像.

主要方法:

利用基于反射矩阵记录的超声波矩阵成像,以补偿波浪扭曲.
在麻醉羊身上进行了体内实验,以重建深层大脑微血管.
采用微气泡对比剂进行超快速成像,以提高信号噪声比和超高分辨率.

主要成果:

超声波矩阵成像有效地弥补了跨膜超声波中的波浪扭曲.
观察到显著增强对比度和ULM的分辨率.
在羊中成功地在体内重建了深层大脑微血管.

结论:

超声波矩阵成像提供了一个可行的解决方案,以克服跨骨ULM的基本局限性.
补偿的ULM显示为非电离,深度大脑微血管成像的前景.
这种方法可以推进观察人类大脑微血管病理,如中风.

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