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Updated: Sep 13, 2025

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在PBPK模型中选择参数子集的特性变化和不确定性.

Celia M Schacht1, Dustin F Kapraun1, Annabel E Meade2

  • 1Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, United States.

Toxicological sciences : an official journal of the Society of Toxicology
|July 30, 2025
PubMed
概括

基于生理学上的药理动力学 (PBPK) 模型估计人类等效剂量 (HED). 全球敏感性分析 (GSA) 有助于确定影响极端HED百分位数的关键参数,以改善风险评估.

关键词:
基于生理学的药理动力学.人类风险评估人类风险评估数学建模的数学建模灵敏度分析是一种灵敏度分析.不确定性量化不确定性量化

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