血清维生素B12,叶酸,HOMOCYSTEINE和葡萄糖控制标记在2型糖尿病患者中,由METFORMIN和其他口服抗糖尿病药物治疗
A Al-Samydai1, A Oraibi2, S Altamimi3
11Department of Pharmacy, Pharmacological and Diagnostic Research Center, Al-Ahliyya Amman University, Amman, Jordan.
Georgian medical news
|July 30, 2025
概括
在2型糖尿病患者中长期使用甲福明与较低的维生素B12和较高的同类半氨酸水平有关. 建议对接受甲福林治疗的人进行常规维生素B12监测,以预防缺乏症并发症.
科学领域:
- 内分泌学 在内分泌学.
- 营养生物化学 营养生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2DM) 是一种广泛的代谢障碍,具有潜在的长期并发症.
- 作为T2DM的主要治疗药物,甲福明可能会导致营养物质的吸收不良,特别是维生素B12缺乏,可能导致高血糖蛋白和代谢功能障碍.
研究的目的:
- 调查甲福明和其他口服抗糖尿病药物 (OAD) 对T2DM患者血清维生素B12,叶酸和同类半素水平的影响.
- 评估这些营养水平和血糖控制标志物之间的关系.
主要方法:
- 一项涉及330名参与者的研究,包括健康的对照组和接受甲福林,其他OAD或不接受药物的T2DM患者.
- 使用CMIA和酶分析测量血清维生素B12,叶酸,同类蛋白,禁食血糖 (FBG),HbA1c和肌素的测量.
- 使用克鲁斯卡尔-瓦利斯测试,独立t测试和皮尔森相关性进行统计分析.
主要成果:
- 与其他组相比,甲胺使用者表现出显著更高的同型半氨酸和更低的维生素B12和叶酸水平 (p<0.001).
- 维生素B12水平与年龄,HbA1c,同型半氨酸和FBG有显著的负相关性.
- 长期使用 (超过五年) 高剂量甲胺 (超过1000毫克/天) 与显著降低维生素B12水平相关 (p<0.001).
结论:
- 在T2DM患者中,长期使用高剂量的甲福明治疗与血糖控制的降低,同类半氨酸的升高和维生素B12缺乏有关.
- 对于接受长期甲福林治疗的患者来说,定期监测维生素B12水平至关重要,以减轻与缺乏症相关的风险.
相关概念视频
Oral Hypoglycemic Agents: Biguanides and Glitazones
304
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
304
Diabetes: Management and Pharmacotherapy
393
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
393
Diabetes Mellitus: Type 2 and Gestational
3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
263
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
263
Diabetes: Symptoms, Diagnosis, and Complications
694
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
694
Diabetes Mellitus: Overview and Type I Subtype
3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.3K


