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在2型糖尿病患者中,抗甲状腺氧化剂抗体水平和甲状腺功能概况之间的关联
N Alansari1, M Ismail1, S Omer1
11Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University.
Georgian medical news
|July 30, 2025
概括
抗甲状腺过氧化酶 (ATPO) 抗体升高的2型糖尿病患者面临甲状腺功能障碍的风险增加. 建议所有糖尿病患者定期进行甲状腺查.
科学领域:
- 内分泌学 在内分泌学.
- 临床生物化学 临床生物化学
背景情况:
- 2型糖尿病 (T2DM) 和甲状腺功能障碍是常见的内分泌疾病.
- T2DM患者表现出较高的甲状腺功能低下症和甲状腺功能增强症的患病率.
- 在不受控制的T2DM中,胰岛素抵抗会影响甲状腺功能;甲状腺自身免疫性涉及自身抗体.
研究的目的:
- 为了研究抗甲状腺过氧化酶 (ATPO) 抗体水平和甲状腺功能概况在阿贾曼,阿联的2型糖尿病患者之间的关联.
主要方法:
- 在阿联阿贾曼的Thumbay医院进行横截面研究.阿联阿贾曼.
- 采集的样本检测了禁食血糖 (FBG),HbA1c,ATPO,甲状腺刺激激素 (TSH),自由T3 (FT3) 和自由T4 (FT4).
- 使用光谱光度,电化学发光和免疫度测量方法进行分析.
主要成果:
- 在T2DM患者和非糖尿病对照者之间发现了FBG,HbA1c,TSH,FT3和ATPO水平的显著差异.
- 糖尿病小组显示HbA1c,FBG,TSH和ATPO (受控与不受控制) 以及HbA1c,FBG,TSH和FT4 (男性与女性) 的显著变化.
- 在ATPO水平和FBG,HbA1c和TSH之间观察到正相关性.
结论:
- 在T2DM患者中ATPO抗体升高表明未来存在功能性甲状腺问题的风险.
- 糖尿病人和非糖尿病人的甲状腺特征存在着显著的区别.
- 在T2DM中,TSH和ATPO之间的积极关联表明自身免疫在糖尿病中的作用;定期的甲状腺查对糖尿病患者至关重要.
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