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通过纳米粒子在固体瘤中的结构重编程:一篇综述

Farag M A Altalbawy1, Uday Abdul-Reda Hussein2, Suhas Ballal3

  • 1Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.

Bioorganic chemistry
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概括

纳米粒子提供精确的输送瘤 stromal 重编程,癌症治疗的关键策略. 这种方法向瘤 stromal 细胞,以克服治疗耐药性并提高治疗疗效.

关键词:
癌症 癌症 癌症 癌症免疫治疗是一种免疫疗法.纳米颗粒 纳米颗粒电流重编程 电流重编程瘤 瘤 瘤 瘤

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科学领域:

  • 在瘤学瘤学.
  • 纳米技术 纳米技术
  • 生物医学工程 生物医学工程

背景情况:

  • 瘤微环境,特别是肌层,在瘤的进展和对癌症治疗的抵抗方面发挥着至关重要的作用.
  • 瘤 stromal 细胞是瘤微环境的组成部分,是重要的治疗点.

研究的目的:

  • 提供纳米粒子应用在瘤 stromal 重编程用于癌症治疗的全面审查.
  • 探索当前的理解,各种纳米粒子类型,准策略和这个快速发展的领域的治疗潜力.

主要方法:

  • 对基于纳米粒子的瘤 stromal 重编程的当前文献的综述.
  • 将纳米粒子分为有机和无机类型的分类.
  • 对瘤 stromal 细胞的被动和主动向策略的分析.
  • 对纳米粒子疗法的临床前和临床研究的评估.

主要成果:

  • 纳米粒子能够精确地将治疗剂输送到瘤 stromal 细胞,从而促进瘤微环境的调节.
  • 已经开发出各种有机和无机纳米颗粒来向树.
  • 无论是被动的还是主动的向策略,都显示出在将纳米颗粒引导到树皮细胞方面具有前途.

结论:

  • 基于纳米粒子的瘤 stromal 重编程为癌症治疗提供了一种新且有前途的治疗策略.
  • 需要对临床前和临床应用进行进一步的研究,才能充分发挥这些方法的潜力.