HCC免疫格局中的表观遗传机制:治疗意义
Maite G Fernandez-Barrena1, Iker Uriarte2, Pablo Sarobe3
1Hepatology Laboratory, Solid Tumors Program, CIMA, CCUN, University of Navarra, Pamplona, Spain; Instituto de Investigaciones Sanitarias de Navarra IdiSNA, Pamplona, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.
Seminars in immunology
|July 30, 2025
概括
利用表观遗传药物可以在肝细胞癌 (HCC) 中克服免疫检查点抑制剂 (ICI) 的耐药性. 这种方法可以提高免疫冷瘤患者的治疗疗效,改善肝癌的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 目前,将免疫检查点抑制剂 (ICI) 与抗VEGF/VEGFR抗体结合在一起的治疗方法仅对大约30%的晚期HCC患者有益,通常是免疫热瘤患者.
- 对ICI治疗的耐药性仍然是HCC治疗的一个重大挑战.
研究的目的:
- 审查表观遗传改变在塑造瘤微环境 (TME) 和HCC.免疫细胞表型中的作用.
- 探索表观遗传修饰如何在肝细胞癌中对免疫检查点抑制剂 (ICI) 的抵抗有助.
- 讨论表观遗传疗法 ("epi-药物") 与ICI协同作用并克服HCC治疗耐药性的潜力.
主要方法:
- 文献综述和临床前证据的综合.
- 对影响TME内的癌细胞和免疫成分的表观遗传机制的分析.
- 讨论针对HCC.的表观遗传修饰的新兴治疗策略.
主要成果:
- 表观遗传改变对癌症的发展至关重要,并影响TME,影响抗瘤免疫力.
- 这些表观遗传变化可以推动瘤的进展,并有助于对ICI等疗法的耐药性.
- 临床前数据表明,结合发性药物和ICI可以提高各种癌症类型的治疗疗效.
结论:
- 癌症和免疫细胞中的表观遗传重编程可以阻碍ICI在HCC中的有效性.
- 针对表观遗传途径提供了一个有希望的策略,使"免疫感冒"的HCC瘤对ICI治疗敏感.
- 涉及表观遗传疗法和ICI的组合策略有可能治疗晚期HCC并改善患者的治疗结果.
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