将PFOS暴露与慢性病联系起来:一个综合流行病学,网络毒理学和实验验证的多模式研究
Xulei Zuo1, Shiyi Tan1, Yuxi Zhang1
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.
Ecotoxicology and environmental safety
|July 30, 2025
概括
perfluorooctane sulfonate (PFOS) 的暴露与慢性病 (CKD) 有关. 这项研究确定了参与PFOS诱导的损伤的关键基因和途径,表明了传统中医的潜在治疗方法.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- perfluorooctane sulfonate (PFOS) 是一种持久性有机污染物,与各种毒性有关,但其特定的毒机制尚未完全理解.
- 慢性病 (CKD) 代表着一个显著且日益增加的全球健康负担,需要对其潜在原因和潜在干预措施进行研究.
研究的目的:
- 通过使用CKD作为模型,研究PFOS诱导的损伤的分子机制.
- 探索PFOS暴露与CKD流行率之间的关联.
- 为了确定与PFOS相关的毒性潜在的治疗策略.
主要方法:
- 多学科方法包括流行病学分析 (NHANES数据),网络毒理学,蛋白质蛋白相互作用 (PPI) 分析,分子对接和体内动物实验.
- 使用GSE32591数据集进行验证,并构建诊断模型.
- 使用Coremine医疗的传统中医 (TCM) 候选人的查.
主要成果:
- 在血清PFOS水平和CKD患病率之间发现了显著的U形关联.
- 确定了四个枢纽基因 (ALB,PTGS2,AKT1,IGF1),形成了一个具有高精度的诊断模型 (AUC = 0.96).
- 在小鼠中,PFOS暴露引起了剂量依赖的管损伤,损伤标志物 (NGAL,KIM-1) 的升高,并激活了PI3K-AKT通路. 阿斯特拉加卢斯膜显示出治疗潜力.
结论:
- 阐明了PFOS诱导毒性的关键分子标和途径.
- 开发了一种诊断PFOS相关病的诊断模型.
- 传统中国医学,特别是Astragalus membranaceus,作为治疗PFOS诱导的损伤的治疗策略有前途.
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