在患有叶和非典型语言组织的患者中,功能和结构性语言相关的大脑网络
Mehmet Salih Yildirim1, Karl-Heinz Nenning2, Victor Ulrich Schmidbauer3
1Department of Neurosurgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Developmental and Interventional Neuroimaging Lab (DINLAB), Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Comprehensive Center for Clinical Neuroscience and Mental Health, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
患有非典型语言组织的患者在下额头回环 (IFG) 中显示出右半球连接性增加,这与持续时间相关. 这一发现有助于理解中大脑重组的过程.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 脑部成像 脑部成像
背景情况:
- 与大脑变化有关,非典型的语言组织 (ALO) 比健康个体更常见.
- 叶 (TLE) 患者经常表现出大脑功能和结构组织的改变.
研究的目的:
- 研究ALO与左半球语言主导 (LLD) 的TLE患者的结构连接差异.
- 利用概率学路径学来比较TLE患者群体之间的大脑网络.
主要方法:
- 包括22名患有ALO的TLE患者和27名患有LLD的TLE患者,使用3台特斯拉fMRI进行评估.
- 分析了SPM12的功能语言模式和通过通道图和全脑细分的结构连接.
主要成果:
- 与LLD患者相比,ALO患者的右半球IFG连接性更强 (pFDR=0.030).
- 在右半球TLE的ALO中,IFG和STGfMRI激活与持续时间负相关.
- 在ALO中STG和IFG连接的横向化与持续时间相关.
结论:
- 增加右半球IFG连接是TLE患者ALO的一个关键发现.
- 连接模式与的持续时间相关,这表明大脑的重组.
- 网络分析可以提高对和神经外科结果的理解.
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