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在1.5T系统上使用对比增强的同位素FLAIR*来评估多发性硬化症中的中央静脉标志:一项前性观察研究
Yunus Emre Senturk1, Ahmet Peker1, Hande Ozen Atalay1
1Department of Radiology, Koç University Hospital, Istanbul, Turkey.
Multiple sclerosis and related disorders
|July 30, 2025
概括
在1.5T磁共振成像 (MRI) 上,加多基对比剂 (GBCA) 增强的FLAIR*成像显示了在多发性硬化症 (MS) 中评估中央静脉信号 (CVS) 的良好性能. 虽然效果不如3TMRI,但由于1.5T系统的广泛可用性,它的实用性是显著的.
科学领域:
- 放射学和成像学 放射学和成像学
- 神经学 神经学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 同位体FLAIR*成像中的中央静脉标志 (CVS) 是诊断多发性硬化症 (MS) 的已知成像生物标志物.
- 评估CVS通常涉及先进的MRI技术,通常在更高的场强度,如3T.
研究的目的:
- 评估使用加多基对比剂 (GBCA) 增强的FLAIR*成像在1.5TMRI中用于多发性硬化症 (MS) 中的中枢静脉信号 (CVS) 检测的患病率和有效性.
- 为了比较1.5T GBCA增强FLAIR*与3T GBCA增强FLAIR*的性能,用于CVS评估.
主要方法:
- 一项前性观察性研究包括41名MS患者使用1.5TMRI和28名使用3TMRI,两者均使用GBCA增强的FLAIR*.
- 用NAIMS-CVS标准评估病变的资格,然后由两个评级人员分类为CVS+或CVS-.
- 使用Select-n*和基于百分比的方法确定CVS+病变的患病率.
主要成果:
- 在895个符合条件的病变中,59.7%是1.5T时的CVS+,69.7%是3T时的CVS+.
- 根据Select-3*(+) 和Select-6*(+) 标准,现场实力之间存在很高的基于案例的一致性 (93-96%).
- 基于百分比的分析显示,与1.5T (63% ± 14.8) 相比,在3T (72% ± 13.4) 中的CVS+平均患病率显著更高,p=0.015.5.
结论:
- 在1.5T的MRI中,GBCA增强的FLAIR*显示了在MS中CVS评估中可接受的性能.
- 虽然3T MRI产生了更高的CVS+流行率,但由于其广泛可用性,1.5T系统的结果在临床上具有相关性.
- 进一步的研究可以优化1.5T协议,以提高MS中的CVS检测.
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