黑色素通过通过RORα核受体调节卫星细胞增殖来改善 brojlers的生长和屠宰性能
Shuhui Ma1, Lina Dong1, Aili Fan2
1Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China.
Research in veterinary science
|July 30, 2025
概括
饮食中的黑激素通过增加肌肉百分比和抗氧化能力来提高 brojler 的生长和肉质. 它通过RORα受体促进肌肉细胞的增殖,改善整体性能.
科学领域:
- 动物科学动物科学
- 分子生物学分子生物学
- 营养科学 营养科学
背景情况:
- 黑色素是一种具有已知的抗氧化和增长促进作用的激素.
- 了解其在家禽中的分子机制对于优化生产至关重要.
研究的目的:
- 调查黑激素对肉生长和屠宰性能的影响的分子机制.
- 阐明与视网膜相关的孤儿受体-α (RORα) 在黑素作用中的作用.
主要方法:
- 在42天的时间里,肉被食了补充黑激素 (0-80毫克/公斤) 的饮食.
- 骨肌卫星细胞 (SMSCs) 用黑激素和RORα调节剂 (SR1078,SR3335) 进行治疗.
- 评估了与肌肉生长相关的生长,屠宰性能,抗氧化能力,肉质和基因表达.
主要成果:
- 黑素补充剂降低了料增益率和增加了肌肉百分比,血清黑素,抗氧化能力 (T-AOC,抗氧化酶),并减少了MDA.
- 改善了肉的水容量和肌纤维面积.
- 在肌肉和SMSC中升级调节的Pax7,MyoD,Myf5和降低调节的MSTN表达.
- 黑色素对Pax7,MyoD和Myf5的影响是由RORα激活/抑制调节的.
结论:
- 黑色素促进肉生长和屠宰性能.
- 黑色素通过RORα核受体调节的SMSC增殖.
- 这种机制涉及影响骨肌肉生长相关的基因表达.
相关概念视频
The Pineal Gland
2.6K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
2.6K
Major Hormones and Their Functions
718
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
718
Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Management of Insomnia
323
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
323
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
Biological Clocks and Seasonal Responses
38.5K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
38.5K


