免疫表型在口腔状细胞癌中的预后影响
Michal Herman1, Jaroslav Michalek2, Richard Pink1
1Department of Oral and Maxillofacial Surgery, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Oral oncology
|July 30, 2025
概括
口腔状细胞癌 (OSCC) 免疫表型,特别是免疫沙漠和免疫炎症,与患者的生存率较差有关. 对这些免疫表型的组织学评估可以帮助OSCC预后和治疗决策.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 目前的口腔状细胞癌 (OSCC) 阶段测定缺乏可靠的高风险患者鉴定.
- 瘤的免疫微环境显著影响癌症的发展和进展.
- 需要生物标志物来改善OSCC的预后和预测分层.
研究的目的:
- 研究免疫表型在口腔状细胞癌 (OSCC) 的预后影响.
- 为了将免疫表型与临床病理特征和PD-L1表达相关联.
主要方法:
- 根据瘤透淋巴细胞 (TILs) 将119个OSCC瘤分为免疫排除,免疫炎症和免疫沙漠表型.
- 分析了免疫表型的预后意义和临床病理相关性.
- 与已识别的免疫表型相关的PD-L1表达水平.
主要成果:
- 免疫沙漠和免疫炎症的表型与淋巴结转移,更高阶段,等级和围神经侵入相关.
- 免疫炎症的表型显示,局部复发的发病率更高.
- 免疫沙漠和免疫炎症的OSCC表型都与明显较低的无疾病,疾病特异性和整体生存率有关.
结论:
- 瘤免疫表型的组织学评估为OSCC提供了重要的预后信息.
- 免疫沙漠和免疫炎症的OSCC表型表明由于缺乏抗瘤免疫力或免疫抑制微环境,预后更差.
- 这些发现支持在OSCC危险歧视和治疗决策中使用免疫表型.
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