婴儿接种疫苗后发烧:使用儿童护理移动应用程序进行现实数据分析
Munehiro Furuichi1, Yuki Omoto2, Takeshi Arimitsu1
1Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
Vaccine
|July 30, 2025
概括
接种疫苗后发烧在日本婴儿中很常见,特别是在3个月大的时候. 诸如男性性别,夏季和联合疫苗 (PCV13,DPT-IPV) 等因素会增加发烧的风险.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 发烧是婴儿接种疫苗后常见的反应.
- 了解现实世界的发烧发病率对于家长指导和医疗保健提供者至关重要.
- 日本的疫苗接种计划和常见的疫苗组合需要特别的调查.
研究的目的:
- 为了确定日本婴儿接种疫苗后发烧的实际频率.
- 为了确定与疫苗接种后发烧相关的特定的人口,时间和疫苗相关因素.
主要方法:
- 利用Papatto Ikuji智能手机应用程序的数据,收集疫苗接种和每日温度记录.
- 包括来自2563名2-23个月龄的婴儿和幼儿的5690次疫苗接种事件.
- 采用混合效应物流回归来分析与疫苗接种后发烧相关的因素.
主要成果:
- 接种疫苗后发烧最常发生在3个月大的婴儿 (14.0%).
- 与冬季 (6.3%) 相比,夏季 (9.3%) 发烧率较高.
- 联合使用PCV13,Hib和DPT-IPV疫苗显示,发烧发病率明显高 (16.8%),高于其他组合.
结论:
- 男性性别,年龄较小 (3个月),以及特定的疫苗组合 (PCV13和DPT-IPV) 与发烧风险增加有关.
- 夏季疫苗接种季节与疫苗接种后发烧的频率较高有关.
- 来自儿童护理应用程序的现实数据为婴儿疫苗反应提供了宝贵的见解.
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