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Updated: Sep 13, 2025

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癌症干细胞生物标志物在局部发达的头部和部状细胞癌中

Miguel Caballero-Borrego¹, Juan J Grau², Neus Basté³

¹Hospital Clinic of Barcelona, Otolaryngology Department, Barcelona, Spain; Universitat de Barcelona, Facultat de Medicina i Ciències de la Salut, Department of Surgery and Medical-Surgical Specialties, Barcelona, Spain; Institut d'Investigacions Biomèdiques Agusti Pi Sunyer (IDIBAPS), Barcelona, Spain.

Brazilian journal of otorhinolaryngology

|July 30, 2025

概括

癌症干细胞标记物HLA-I和CD44是局部发达的头部和部状细胞癌 (HNSCC) 存活的独立预后因素. 节点参与也影响患者的结果,指导未来的治疗策略.

科学领域:

在瘤学瘤学.
癌症研究癌症研究
免疫学免疫学免疫学

背景情况:

头部和部状细胞癌 (HNSCC) 是一个重要的全球健康问题.
当地先进的HNSCC带来了复杂的治疗挑战和可变的预后.
癌症干细胞标记物越来越多地被认为对瘤进展和治疗耐药性的作用.

研究的目的:

为了研究癌症干细胞标记物的预后价值 (CD44,HLA-I,泛细胞克拉丁,p-EGFR) 在局部发达的HNSCC.
评估这些标记物在常规临床实践中作为生物标记物的适用性.
为了将标记物表达与整体存活率 (OS) 和无病存活率 (DFS) 相关联.

主要方法:

对104名局部晚期HNSCC患者进行了回顾性分析,这些患者接受了手术和化疗放射治疗.
在手术样本中对CD44,HLA-I,泛细胞克拉丁和p-EGFR进行免疫组织化学评估.
包括Cox多变量分析在内的统计分析,以确定OS和DFS的独立预后因素.

主要成果:

较高的OS率与HLA-I过度表达和CD44表达率较低有关.
节点参与是OS的显著负面预后因素.
HLA-I和CD44表达,以及结节状况,独立地与OS相关.
生物标志物和DFS之间没有发现显著的关联.

结论:

节点参与,HLA-I过度表达和CD44表达减少是局部发达HNSCC生存的独立预后指标.
这些标记物有可能作为HNSCC的常规实践中的预后生物标记物.
进一步的研究可能会根据这些预后因素来完善治疗策略.

关键词:

生物标志物生物标志物 CD4444 是一个CD44 癌症干细胞是癌症干细胞.在 HLA-I 的情况下,头癌是头部和部的癌症.

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