人体循环和组织内存T细胞在不同部位的异步衰老和循环
Nora Lam1, J Carlos Angel2, Bruce A Buchholz3
1Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Immunity
|July 30, 2025
概括
人类内存T细胞根据其位置和类型的不同而有不同的衰老. 组织内存T细胞 (TRM) 持续存在,没有表现出衰老的迹象,与效应器记忆T细胞 (TEM) 不同.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
背景情况:
- 记忆T细胞,包括效应器-记忆 (TEM) 和组织-居民 (TRM) 子集,对于持续的免疫是至关重要的.
- 解剖部位和T细胞子集对人类记忆T细胞的长期持久性和衰老的影响尚未完全理解.
研究的目的:
- 在各种组织中调查与年龄相关的动态和人类记忆T细胞子集 (TEM和TRM) 的持久性.
- 为了确定TRM细胞在人类寿命中是否表现出类似于TEM细胞的免疫性.
主要方法:
- 利用回顾性放射性碳 (C) 出生日期来评估记忆T细胞的年龄.
- 采用细胞,转录组和表观遗传分析,分析来自淋巴体器官,粘膜部位和血液的T细胞种群,跨越广泛的年龄范围 (10年).
主要成果:
- 周边部位的记忆T细胞平均寿命为1-2年,在脏中发现的寿命更长的细胞.
- 效应器记忆 (TEM) 细胞会随着年龄的增长积累衰老标记和GZMK签名.
- 组织居民 (TRM) 细胞保持特定位点的表型,并且不显示衰老,尽管与年龄相关的DNA低甲基化.
结论:
- 人类记忆T细胞表现出异步衰老模式,取决于它们的子集和解剖位置.
- 组织内存T (TRM) 细胞表现出了显著的持久性,而没有经历免疫性,这表明它们具有独特的长期保护性免疫作用.
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