在患有肺癌的患者中 Sarcopenia,体质指数升高和相关的不良事件
Jiaxuan Lyu1,2,3, Lea Mantz4,5, Nurit S Katz-Agranov2,6
11MMSCI Program, Harvard Medical School, Boston MA.
概括
加上高BMI的萨尔科佩尼亚增加了接受化疗的非小细胞肺癌患者不良事件的风险. 这可能是由于这些人的功能估计不准确.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有非小细胞肺癌 (NSCLC) 和肉类 (肌肉质量低) 以及体重指数 (BMI) 升高的患者,面临基化疗不良事件 (AE) 的风险更高.
- 确定预测化疗毒性的因素对于优化NSCLC治疗和患者结果至关重要.
研究的目的:
- 调查萨尔科佩尼亚,BMI升高和在NSCLC患者中发生与相关的AE的相关性.
- 探索萨科佩尼亚和BMI对化疗中止和死亡率的影响.
- 评估估计的膜过率 (GFR) 错误计算在卡博普拉丁剂量和随后的副作用中的作用.
主要方法:
- 在2015-2022年期间,对604名成年NSCLC患者进行了回顾性队列研究,这些患者接受了 Cisplatin 或 Carboplatin 的治疗.
- 使用计算机断层扫描 (CT) 扫描和性别特异性骨肌指数切断来评估萨尔科佩尼亚.
- 细灰分布危险模型被用于分析萨尔科佩尼亚,BMI和等级≥2AEs,化疗中止和90天死亡率之间的关联.
主要成果:
- 麻症和升高的BMI显著与增加≥2级贫血,血小板缩和肌素升高的风险有关.
- 与正常BMI患者相比,患有sarcopenia和BMI升高的患者具有更高的特定AE风险.
- 敏感性分析表明,GFR估计的差异 (Cockcroft-Gault与CKD-EPI) 导致高卡博普拉丁剂量与增加的副作用和化疗中止相关.
结论:
- CT定义的肉症和高BMI的组合与在NSCLC患者中与相关的AE的更高发病率有关.
- 低肌肉质量和高BMI患者的GFR误估可能会导致AEs增加和化疗停止.
- 这些发现凸显了在接受化疗的NSCLC患者中考虑身体组成和准确的GFR评估的重要性.
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
01:21Overview of Protein Metabolism
1.9K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.9K