基因组证据表明,厄瓜多尔有Orthobunyavirus的活跃传播
Daniel Romero-Alvarez1, Juan Carlos Navarro2, Diana Gutiérrez-Pallo3
1Research Group of Emerging and Neglected Diseases, Ecoepidemiology and Biodiversity, Health Science Faculty, School of Biomedical Sciences, Universidad Internacional SEK (UISEK), Quito, Ecuador; Instituto Nacional de Biodiversidad (INABIO), Quito, Ecuador.
概括
厄瓜多尔正在传播口口热病毒 (OROV),与巴西流行病菌株不同. 持续的基因组监测对于检测和预防未来这种Orthobunyavirus的动物性疾病爆发至关重要.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 基因组监测 基因组监测
背景情况:
- 迄今为止有记录的最大的Oropouche热病流行病发生在2023-2025年间在巴西,病例蔓延到拉丁美洲.
- 2024年在厄瓜多尔报告了三起Oropouche热病例,突出了区域传播.
研究的目的:
- 在厄瓜多尔检测到的Oropouche病毒 (OROV) 菌株的特征.
- 了解Oropouche病毒与该地区其他菌株的遗传关系.
- 评估厄瓜多尔的Orthobunyavirus oropoucheense的特有性和未来爆发的可能性.
主要方法:
- 用RT-qPCR进行初步口腔病毒 (OROV) 诊断.
- 下一代测序用于病毒基因组分析.
- 遗传学分析以确定遗传关系.
主要成果:
- 2024年6月,在厄瓜多尔发现了一种新的OROV菌株.
- 这种菌株与另一个2024年的厄瓜多尔分离物共享遗传段 (L和S),但与早期的厄瓜多尔菌株和2023-2025年的巴西流行病菌株不同.
- 这些发现表明,奥罗普什病毒在厄瓜多尔具有特有循环模式.
结论:
- 在厄瓜多尔,Orthobunyavirus oropoucheense是本土的.
- 在厄瓜多尔及其他地区,应该持续对奥尔托布尼亚病毒进行基因组监测.
- 积极的监测对于预测潜在的动物传染病爆发至关重要,独立于流行病活动.
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