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异quercitrin:从自然来源到临床候选人 - 合成,药理学和代谢安全性

Bocui Song¹, Wenqi Niu¹, Haice Sun¹

¹College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.

|July 30, 2025

概括

异quercitrin (ISQ) 是一种具有广泛治疗潜力的植物类黄. 本综述详细介绍了其机制,包括抗氧化和抗炎途径,并强调需要改善口服生物可用性.

科学领域:

药理学和自然产品化学化学
生物化学和分子生物学

背景情况:

异quercitrin (ISQ) 是一种在各种植物中发现的黄类化合物.
ISQ在多个身体系统中表现出显著的治疗效果.
现有的研究突出了ISQ的潜力,但需要进行全面的分析.

研究的目的:

系统地审查Isoquercitrin (ISQ) 的药理机制,毒性,合成和药理动力学.
巩固有关ISQ生物活动和治疗应用的当前知识.
确定未来的研究方向和ISQ的临床翻译途径.

主要方法:

在Web of Science,谷歌学者,科学直播和PubMed (2015年至今) 的系统文献搜索.
根据纳入标准选了1694篇文章,其中117篇研究被选中进行分析.
对药理机制,毒性,合成方法和药理动学的全面评估.

主要成果:

通过JAK/STAT3,Nrf2/ARE,NF-κB,AMPK,PI3K/Akt和Wnt通路,ISQ产生影响.
显示出抗炎,抗氧化,代谢调节和瘤抑制的特性.
诱导选择性癌细胞死亡,并表现出较低的口服生物利用性,需要改进配方.

结论:

异quercitrin (ISQ) 具有由复杂的分子机制驱动的多方面的药理活动.
进一步的研究和配方开发对于优化ISQ的治疗疗效和临床应用至关重要.
本综述提供了ISQ当前研究环境的全面概述.

关键词:

生物可用性生物可用性生物活动是生物活动.这种类型的黄类化合物.伊索克尔西特林 (Isoquercitrin) 是一种可以

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