来自内生菌真菌Phomopsis tersa SC5100SC5100的新生物活跃的皮里类类化合物和pyranones
Fangfang Duan1, Linjie Wei1, Yunfei Yuan1
1State Key Laboratory of Plant Diversity and Specialty Crops, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
Fitoterapia
|July 30, 2025
概括
来自Phomopsis tersa的新型pyridone类化合物和pyranones表现出强大的免疫抑制和α-glycosidase抑制活性. 这些化合物显示出治疗开发的前景.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 内生菌是新型生物活性化合物的丰富来源.
- 众所周知,Phomopsis物种可以产生各种具有药理潜力的二次代谢产物.
研究的目的:
- 从内生菌真菌Phomopsis tersa中分离和鉴定新的皮里类类化合物和pyranones.
- 评估分离化合物的免疫抑制和α-糖酶抑制活性.
主要方法:
- 这是一种Phomopsis tersaSC5100.的固体培养物.
- 使用NMR,HRESIMS,单晶X射线衍射和ECD计算进行结构阐明.
- 在体外测定免疫抑制活性 (T和B细胞增殖) 和α-糖酶抑制.
主要成果:
- 鉴定出了三种新的皮里类化物 (1-3) 和三种新的皮拉 (4-6),以及六种已知的化合物.
- 化合物1-3对T和B细胞增殖表现出显著的免疫抑制作用.
- 化合物4-6和9-12表现出中度至优异的α-糖酶抑制活性.
结论:
- 菲莫普西斯·特尔萨 (Phomopsis tersa) 含有生物活性皮里顿类化合物和皮拉诺的化学型.
- 隔离的化合物具有有前途的免疫抑制和酶抑制特性,需要进一步研究治疗应用.
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