三甘油糖指数和心房动之间的关联:系统性审查和元分析
Qiang Chen1, Jianqiang Zhao1, Wei Wang1
1Department of Cardiology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Asia Pacific journal of clinical nutrition
|July 30, 2025
概括
三甘油糖 (TyG) 指数是胰岛素抵抗的标志物,与心房动 (AF) 的更高风险有关. 这一系统性审查和元分析证实了Tyg指数水平升高与AF发病率之间的积极关联.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 胰岛素抵抗 (IR) 是心房动 (AF) 的已知危险因素.
- 三甘油糖 (TyG) 指数是IR的验证指标.
- 之前的研究表明,TyG指数和AF之间存在相关性,需要进一步调查.
研究的目的:
- 系统地审查和对现有研究进行元分析.
- 调查TyG指数与AF风险之间的关联.
- 评估TyG指数水平与AF风险之间的线性趋势.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science等) 进行系统的文献搜索. 在2024年8月之前.
- 包括17项研究,共有57,213名参与者.
- 应用随机效应模型和暴露效应分析,用于聚合估计和趋势评估.
主要成果:
- 在AF患者中,TyG指数显著更高 (SMD:0.78;p<0.001).
- 在连续 (OR:1.80;p<0.001) 和分类分析 (OR:1.98;p<0.001) 中,TyG指数与AF风险呈正相关性.
- 证实了TyG指数和AF风险之间的线性正相关性 (p=0.006).
结论:
- 泰格指数与心房的风险增加有关.
- 这种关联扩展到各种AF类型,包括术后AF和AF复发后去除.
- 需要进一步的研究来确定TyG指数和AF之间的因果关系.
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