维生素B-12的低水平与成年人中潜伏的结核病感染之间的关联
Liping Jiang1, Taoli Yan1, Xueqian Zhang1
1Department of Nutrition, School of Public Health, Qingdao University, Qingdao, China.
Asia Pacific journal of clinical nutrition
|July 30, 2025
概括
维生素B-12缺乏与美国成年人患潜伏结核病感染 (LTBI) 的更高患病率有关. 维持足够的维生素B-12水平可能有助于预防LTBI.
科学领域:
- 营养免疫学 营养免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 是一个全球性的健康问题,潜伏结核病感染 (LTBI) 是活跃疾病的前体.
- 维生素B-12对于免疫功能和Mycobacterium结核病 (MTB) 代谢至关重要.
- 维生素B-12缺乏对结核病的影响,特别是LTBI,需要进一步调查.
研究的目的:
- 调查维生素B-12缺乏和潜伏性结核病感染 (LTBI) 之间的联系.
- 分析国家健康和营养检查调查 (NHANES) 的数据,以发现这种相关性.
主要方法:
- 使用NHANES 2011-2012数据进行横截面研究.
- 包括成人 (≥18岁) 具有可用的血清维生素B-12,甲基马龙酸 (MMA) 和QuantiFERON-TB金 (QFT-GIT) 结果.
- 使用多变量逻辑回归分析来评估相关性.
主要成果:
- 分析了4773名受试者,其中479人被确定为LTBI.
- 较高比例的LTBI参与者表现出低维生素B-12水平.
- 维生素B-12缺乏与LTBI的几率增加了37% (OR: 1.37;95%CI: 1.01-1.85),特别是在35岁以上的成年人和女性中.
结论:
- 维生素B-12缺乏与美国成年人中LTBI的患病率增加有显著关联.
- 保持最佳的维生素B-12状态可能为LTBI预防带来好处.
- 需要进一步的研究来阐明维生素B-12在MTB感染中的临床影响.
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