在体外测试用延长释放divalproex片对药科贝索亚形成的试验
Thais Lizondo López1, Silvia González Suárez1, Carmen López-Cabezas1
1Servicio de Farmacia, Área del medicamento, Hospital Clínic Barcelona, Barcelona, Spain.
概括
大量摄入延长释放的二烯酸可以形成药物虫. 一个体外模型证实了pharmacobezoar的发展,并模拟了高酸水平,这对于毒理管理至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 大量摄入延长释放二甲酸可导致有毒水平.
- 药物形形成是药物过量服用的潜在并发症.
- 了解药物配方对药科动物发育的影响至关重要.
研究的目的:
- 为了评估在大量摄入延长释放二甲 (divalproex sodium) 后的药科贝索亚形成.
- 使用体外模型来模拟胃状况并评估药物动物的发育.
- 为了将体外发现与患者血清酸度相关联.
主要方法:
- 使用欧洲药典模拟的胃液建立了模拟胃状况的体外模型.
- 药科贝的大小和pH值被测量在不同的时间间隔,长达24小时.
- 血清氨酸度在体外测定,并与患者数据进行比较.
主要成果:
- 在体外模型中,在2小时内形成了一个稳定的5厘米x6厘米的药物.
- 在体外测试表明,酸的峰值度与患者的峰值血清度 (656微克/毫升) 类似,大约24小时左右.
- 药科贝索亚在24小时内保持稳定.
结论:
- 在体外实验支持了从延长释放二甲酸过量中形成药科贝索亚的假设.
- 识别容易形成药物体的药物配方对于有效的毒理管理至关重要.
- 这项研究强调了在过量服用病例中考虑药物配方的重要性.
相关概念视频
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01:09Methods for Studying Drug Absorption: In situ
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354