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Updated: Sep 13, 2025

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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RalGAP瘤抑制综合体的结构和机制

René Rasche1, Björn Udo Klink2,3, Lisa Helene Apken4

  • 1Institute of Biochemistry, University of Münster, Münster, Germany.

Nature communications
|July 30, 2025
PubMed
概括

拉尔GTP酶激活蛋白 (RalGAP) 复合体抑制癌症驱动的Ras信号. 我们确定了RalGAP的结构,揭示了它的四度结构以及子单元如何相互稳定以实现体内功能.

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