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相关概念视频

Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

5.8K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
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Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
3.2K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.9K
Drug Distribution: Overview01:11

Drug Distribution: Overview

300
Drug distribution within the body is a dynamic process involving the movement of a drug in two directions across various compartments: from the bloodstream into tissues (tissue uptake) and from tissues back into the bloodstream (tissue release or redistribution). This process is passive and primarily driven by two variables: the concentration gradient between the bloodstream and the extravascular tissues and the drug's ability to cross the cell membrane.
Initially, the free drug in the...
300
Drug Distribution: Volume of Distribution01:25

Drug Distribution: Volume of Distribution

6.0K
The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
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Drug Distribution: Plasma Protein Binding01:29

Drug Distribution: Plasma Protein Binding

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Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
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相关实验视频

Updated: Sep 13, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

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BSVA:在药物可追溯性框架中用于交易管理的区块链支持的安全垂直聚合算法.

P Bhuvaneshwari1, Y Harold Robinson2, M Bagya Lakshmi2

  • 1Manipal Institute of Technology Bengaluru, Manipal Academy of Higher Education, Manipal, India. bhuvaneshwari.p@manipal.edu.

Scientific reports
|July 30, 2025
PubMed
概括
此摘要是机器生成的。

一个新的区块链支持的安全垂直聚合算法 (BSVA) 提高了药物可追溯性. 该系统确保了制药产品的完整性和供应链安全,而无需中央机构.

关键词:
区块链技术 区块链技术 区块链技术证书颁发机构是证书颁发机构.药物可追溯性系统 药物可追溯性系统有保障的垂直聚合算法供应链管理 供应链管理

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Automating Aggregate Quantification in Caenorhabditis elegans
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Automating Aggregate Quantification in Caenorhabditis elegans

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相关实验视频

Last Updated: Sep 13, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
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Automating Aggregate Quantification in Caenorhabditis elegans
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Automating Aggregate Quantification in Caenorhabditis elegans

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科学领域:

  • 供应链管理 供应链管理
  • 信息安全 信息安全
  • 分布式账本技术 分布式账本技术

背景情况:

  • 制药供应链依赖于药物追踪系统来追踪药物.
  • 确保整个供应链中药品的完整性和安全性是一个关键的挑战.
  • 目前的系统可能面临隐私,可扩展性和透明度方面的局限性.

研究的目的:

  • 提出一个新的区块链支持的安全垂直聚合算法 (BSVA),以提高药物可追溯性.
  • 为了利用区块链技术实现安全和分散的制药供应链管理系统.
  • 为了改善药物跟踪中的隐私,可扩展性和交易响应时间.

主要方法:

  • 使用超级账本模型开发一个支持区块链的安全垂直聚合算法 (BSVA).
  • 实施一个分散的框架,以透明交易的链代码.
  • 部署智能合约,通过认证机构进行安全的数据共享和交易处理.
  • 利用强大的聚合用于本地模型处理和链代码执行.

主要成果:

  • 拟议的BSVA模型尽量减少对中央权威的需求,增强数据隐私.
  • 该系统展示了改进的可扩展性,减少了区块链交易的响应时间.
  • 绩效指标证实了BSVA在加强整体药物可追溯系统方面的效率.
  • 该算法确保了整个供应链中制药产品的完整性.

结论:

  • BSVA为制药药物可追溯性提供了一个安全,私有和可扩展的解决方案.
  • 通过BSVA,区块链技术显著提高了供应链管理和产品完整性.
  • 拟议框架的分散性质保证了高交易透明度和安全性.