合成,表征,晶体工程,DFT,和生物评价的新Cu (II) - 酸盐希夫基复合物的基础复合物
Dhrubajyoti Majumdar1, Jessica Elizabeth Philip2, Sourav Roy3
1Department of Chemistry, Tamralipta Mahavidyalaya, Tamluk, 721636, West Bengal, India. dmajumdar30@gmail.com.
BMC chemistry
|July 30, 2025
概括
这项研究合成了一种新的铜(II) 希夫基复合物,在传感和治疗方面具有潜在的应用. 该综合体表现出显著的抗微生物和抗癌活性,得到了DFT分析和结构-活性关系的支持.
科学领域:
- 协调化学 协调化学
- 晶体工程公司 晶体工程
- 材料科学 材料科学 材料科学
背景情况:
- 在协调化学中的晶体工程推动了晶体组装方面的创新.
- 希夫基联体在形成具有多种应用的金属复合体方面具有多样性.
研究的目的:
- 合成和描述一个新的二核铜 (II) 复合体.
- 研究其半导体和传感性能.
- 评估其抗微生物和抗癌活动.
主要方法:
- 一个新的Cu (II) 希夫基复合物的合成.
- 使用SEM-EDX,XPS和单晶X射线衍射 (SCXRD) 的表征.
- 密度函数理论 (DFT) 分析电子属性和传感能力.
- 抗微生物和体外抗癌活性测定.
主要成果:
- 双核Cu (II) 复合体在三临床空间组P-1中结晶,由C-H···π和键稳定.
- 通过电子电荷转移 (ECT) 过程,DFT分析支持半导体和阴离子/离子传感能力.
- 该综合体表现出显著的抗微生物活性,对抗格拉姆阳性/阴性细菌和真菌.
- 实验室试验显示,对HepG2和H9c2癌细胞系具有显著的抗癌活性.
结论:
- 合成的Cu (II) 希夫基复合体显示出在传感器和治疗中应用的前景.
- 结构-活性关系 (SAR) 分析解释了观察到的生物活动.
- 结合的DFT和生物数据突出显示了这种Cu (II) 复合物的新性和潜力.
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