全球和区域大脑测量对认知能力的纵向影响
Fatemeh Hosseininasabnajar1, Lisa Kakinami2,3,
1Department of Mathematics and Statistics, Concordia University, 1455 de Maisonneuve West, Montreal, QC, H3G 1M8, Canada.
Scientific reports
|July 30, 2025
概括
随着时间的推移,脑组织损失会影响认知,特别是在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中. 整个大脑体积影响认知率,而特定区域影响认知水平,但不一定影响认知下降的速度.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 老龄化自然涉及大脑组织和认知能力下降,但纵向数据很少.
- 了解这些变化对于诊断和治疗神经退行性疾病,如阿尔茨海默病 (AD) 至关重要.
研究的目的:
- 为了研究大脑结构和认知功能之间的纵向关系,在整个认知谱的个体.
- 区分全球和区域大脑测量对认知状态及其变化速度的影响.
主要方法:
- 利用来自阿尔茨海默病神经成像计划 (ADNI) 的数据,其中有814名参与者.
- 采用混合效应模型来分析大脑体积/厚度和认知得分之间的纵向关联,超过2-3年.
- 控制共变量以隔离大脑测量对认知的影响.
主要成果:
- 全脑体积显著影响了轻度认知障碍 (MCI) 或AD的个体的认知变化速度.
- 区域大脑测量,包括海马体积,心室体积和内腔皮层厚度,显示了与认知能力的差异关联.
- 这些区域措施影响了认知水平,但没有显著改变认知衰退的速度.
结论:
- 大脑结构,特别是整个大脑体积,在神经退行性疾病中认知能力下降的速度方面发挥着作用.
- 特定的大脑区域可能会影响认知功能水平,但它们对变化速度的影响需要进一步调查.
- 这些发现强调了大脑解剖学与衰老和疾病中的认知轨迹之间的复杂相互作用.
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