识别风险因素和评估治疗干预措施,以治疗术后食道状细胞癌的异位性复发
Tiantian Cui1,2, Huajian Chen1, Min Fan3
1School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC cancer
|July 31, 2025
概括
食道状细胞癌 (ESCC) 手术后的复发影响了生存率. 辅助放射治疗有效减少淋巴结复发 (LNR),改善ESCC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射疗法 辐射疗法
背景情况:
- 手术后复发显著影响食道状细胞癌 (ESCC) 的存活率.
- 了解不同的复发模式,如解瘤复发 (AR) 和淋巴结复发 (LNR),对于患者管理至关重要.
- 辅助放射治疗是一种潜在的策略,可以缓解手术后的复发.
研究的目的:
- 为了研究解瘤复发 (AR) 和淋巴结复发 (LNR) 对ESCC患者的生存的影响.
- 评估辅助放射治疗在改变术后复发模式方面的疗效.
- 为优化ESCC的临床管理策略提供见解.
主要方法:
- 对434名经过彻底手术的ESCC患者进行了回顾性队列分析.
- 使用后勤和考克斯比例危险回归模型来确定AR和LNR的风险因素.
- 卡普兰-梅尔生存分析被用来评估生存结果.
主要成果:
- 晚期N阶段和LNR被确定为复发的重大风险因素.
- 患有AR的患者的中位生存时间为21个月.
- 辅助放射治疗显著降低了LNR发生率和整体复发率,改善了生存结果.
结论:
- 手术后复发是ESCC生存的主要决定因素.
- 辅助放射治疗通过减少复发,特别是LNR,显示出预后意义.
- 风险分层和主动管理,包括合理使用辅助放射治疗,对于改善ESCC患者预后至关重要.
更多相关视频
相关概念视频
Esophageal Strictures-I: Introduction
269
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
269
Barrett Esophagus-II: Clinical Manifestations and Management
305
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
305
Esophageal Strictures-II: Clinical Features and Management
160
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
160
Barrett Esophagus-I: Introduction
210
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
210
Esophageal Perforation-II: Clinical Manifestations and Management
149
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
149
Peptic Ulcer Disease V: Surgical Management and Nursing Care
412
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
412


