Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inhaled Medications01:23

Inhaled Medications

394
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
394
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

468
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

3.1K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
3.1K
Vaporization01:18

Vaporization

35.8K
The physical form of a substance changes by changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. For vaporization to occur, kinetic energy must be greater than the intermolecular forces that keep molecules bonded. The amount of energy needed to vaporize a quantity of liquid at a given pressure and a constant temperature is called the heat of vaporization. When...
35.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview.

MedComm·2026
Same author

Discordantly Low HbA1c in Patients Receiving Dapsone: Prevalence and Associations with Hemolysis and Methemoglobinemia.

International journal of endocrinology and metabolism·2026
Same author

From discovery to therapeutic development of monoclonal antibodies.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Dataset documentation for responsible AI: analysis of suitability and usage for health datasets.

NPJ digital medicine·2026
Same author

Extracorporeal Membrane Oxygenation for Pneumocystis Pneumonia: Outcomes in Patients From the Extracorporeal Life Support Organization.

Critical care explorations·2026
Same author

Outcomes of Abdominal Exploration in ECMO-Supported Patients: A Multicenter ICU Cohort Study.

Journal of cardiothoracic and vascular anesthesia·2026

相关实验视频

Updated: Sep 13, 2025

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.8K

喷雾干燥:用于吸入疫苗开发的有希望的技术.

Sridhar Vemulapalli1, Satish Rojekar2, Manit Gandhi3

  • 1Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, 68198-6025, USA.

Current pharmaceutical biotechnology
|July 31, 2025
PubMed
概括

喷雾干燥为制造可吸入疫苗提供了一种新的方法,克服了传统的输送挑战. 这种技术可以生产用于直接输送肺部的细粉末,增强免疫反应和全球健康可访问性.

关键词:
这是一种可吸入的疫苗.干粉疫苗 疫苗 干粉疫苗免疫反应的免疫反应.粒子的特性 粒子的特性肺部输送是通过肺部进行的.呼吸道粘膜中的呼吸道粘膜喷雾干燥 喷雾干燥系统性免疫反应.

更多相关视频

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

998
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.8K

相关实验视频

Last Updated: Sep 13, 2025

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.8K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

998
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.8K

科学领域:

  • 疫苗学 疫苗学 疫苗学
  • 材料科学 材料科学 材料科学
  • 制药技术 制药技术 制药技术

背景情况:

  • 传统的疫苗输送方法在管理,储存和可访问性方面存在挑战,特别是在资源有限的地区.
  • 吸入性疫苗是一个有希望的替代品,针对呼吸道粘膜进行直接的免疫刺激.
  • 喷雾干燥被探索为开发有效的可吸入疫苗配方的关键技术.

研究的目的:

  • 审查喷雾干燥在制备可吸入疫苗方面的潜力.
  • 突出如何喷雾干燥可以克服传统疫苗输送的局限性.
  • 探索喷雾干燥疫苗颗粒的特性及其免疫性.

主要方法:

  • 审查现有的关于用于疫苗配方的喷雾干燥技术的文献.
  • 分析喷雾干燥疫苗引起的粒子特性,空气动力学性能和免疫反应.
  • 对喷雾干燥对于大规模疫苗生产和全球卫生应用的适用性进行评估.

主要成果:

  • 喷雾干燥有效地将液体疫苗配方转化为可吸入的粉末.
  • 喷雾干燥的颗粒显示出适合有效的肺输送的特性.
  • 通过喷雾干燥配制的可吸入疫苗可以诱导显著的粘膜和全身免疫力.

结论:

  • 喷雾干燥是一种通用且有前途的技术,用于开发下一代可吸入疫苗.
  • 这种方法有可能在全球范围内提高疫苗的可访问性,稳定性和有效性.
  • 对喷雾干燥可吸入疫苗的进一步研究和开发可能会彻底改变公共卫生战略.