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通过自我复制RNA作为跨膜免疫原体传递的艾滋病毒Env三元体的增强性幽默反应

Parisa Yousefpour1, Amrit Raj Ghosh2, Himanshi Chawla3

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

Molecular therapy : the journal of the American Society of Gene Therapy
|July 31, 2025
PubMed
概括

传递 RNA (mRNA) 疫苗表达了HIV Env三分体的跨膜 (TM) 或分泌形式,在小鼠中引起了类似的免疫反应. TM格式增强了生殖中心B细胞的选择和广泛中和抗体前体的招募.

关键词:
BG18 BG18 BG18 BG18 BG18 BG18 BG18 BG18 BG18 BG18 BG18 BG18 BG18艾滋病毒 bnAbsbs艾滋病毒的三分体.它们是RNA疫苗.表达方式表达形式表达形式一个复制的RNARNA.

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