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Updated: Jun 29, 2026

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
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使用磁共振光谱测量代谢物水平,用于儿科甲基酸诱导的白内障

Daisuke Hirokawa1, Moyoko Tomiyasu2,3,4, Masaki Sonoda1

  • 1Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Pediatric blood & cancer
|July 31, 2025
PubMed
概括

磁共振光谱学 (MRS) 可以检测N-乙酸和N-乙酸酸 (tNAA) 水平的变化,有助于诊断和监测患有白血病的儿童中甲基酸诱导的白血脑病变. 较低的tNAA水平预示着更高的风险,而增加的水平则表明恢复.

关键词:
磁共振光谱学 磁共振光谱学代谢物生物标志物 生物标志物甲索特雷克萨特诱导的白细胞脑病变儿科神经毒性 儿科神经毒性白质损伤的伤害是什么?

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Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...