维生素D的状态及其与儿童喘控制和严重程度的关联
W M W N Fatin1,2, D Mariana3, A L Hasniah1
1Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Paediatrics, Kuala Lumpur, Malaysia.
The Medical journal of Malaysia
|July 31, 2025
概括
在患有持续性喘的儿童中发现了高水平的维生素D缺乏和不足. 较低的维生素D水平与喘严重程度的增加有关,建议这些患者进行例行检查.
科学领域:
- 儿科肺病学 儿科肺病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 维生素D在调节先天性和适应性免疫力方面起着至关重要的作用.
- 有证据表明,维生素D缺乏与喘严重程度和控制之间存在相关性.
- 喘中的炎症诱导的上皮细胞变化可能与维生素D的免疫调节作用有关.
研究的目的:
- 为了确定患有持续性喘的儿童的维生素D水平.
- 调查维生素D水平与喘严重程度之间的关联.
- 探索维生素D水平与喘控制之间的关系.
主要方法:
- 一项涉及72名患有持续性喘的儿童 (5-18岁) 的横截面研究.
- 使用全球喘倡议 (GINA) 准则评估喘严重程度.
- 使用喘控制测试 (ACT) 或儿童喘控制测试 (c-ACT) 评分来评估喘控制.
- 测量了血清25-基维生素D [25(OH) D]水平;缺陷定义为<52nmol/L,不足为52-73nmol/L.
主要成果:
- 观察到维生素D缺乏 (40.3%) 和缺乏 (38.9%) 的高患病率.
- 平均25 ((OH) D水平为58.74nmol/L.
- 维生素D缺乏与喘严重程度的增加显著相关 (p=0.020).
- 通过GINA分类或ACT/c-ACT得分,没有发现维生素D水平和喘控制之间的显著关联.
结论:
- 患有持续性喘的儿童中有很大一部分患有维生素D缺乏或不足.
- 维生素D缺乏与儿科患者的喘严重程度增加有关.
- 对于中度至重度喘儿童,建议对维生素D水平进行例行评估.
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