多发性硬化症的药物使用:以人口为基础的比较与丹麦一般人口
Josefine Windfeld-Mathiasen1,2,3, Henrik Horwitz1,2, Ida M Heerfordt1,4
1Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Annals of clinical and translational neurology
|July 31, 2025
概括
与普通人群相比,患有多发性硬化症的人使用更多的处方药来治疗症状,包括疼痛和便秘. 这突显了多发性硬化症护理的未满足需求.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经疾病,影响着世界各地的个人.
- 多发性硬化症的治疗通常涉及疾病修饰疗法 (DMT) 和症状治疗.
- 对MS中非DMT药物使用的全面理解对于整体的患者护理至关重要.
研究的目的:
- 为了比较MS患者对处方药的使用情况,不包括DMT,与普通人群相比.
- 确定特定的药物类别和药物,在MS患者和对照人群之间具有差异性的使用模式.
- 为医疗保健策略提供信息,以优化MS中症状和并发症的管理.
主要方法:
- 在丹麦进行了一项全国性的基于登记册的队列研究.
- 包括14,491名被诊断患有多发性硬化症 (20-80岁) 的个人和144,910名来自普通人口的匹配对照.
- 来自丹麦国家处方注册表的处方数据被分析了1年的时间.
主要成果:
- 患有多发性硬化症的个体显著使用止痛药 (51%对33%),便秘药 (12%对3%),抗药和泌尿器科药物的比例更高.
- 在MS队列中,观察到modafinil (RR: 323.33),baclofen (RR: 36.51) 和fesoterodine (RR: 36.36) 的相对风险 (RR) 显著更高.
- 相反,在患有多发性硬化症的人群中,人们注意到抗糖尿病药物和COPD治疗的使用率较低.
结论:
- 这项研究表明,在MS患者的症状和并发症管理中,大量使用非DMT处方药.
- 研究结果强调了除了DMT之外,解决广泛的患者需求的重要性.
- 医疗保健提供者可以利用这些见解来完善患者管理协议,并提高MS患者的整体护理质量.
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