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相关概念视频

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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相关实验视频

Updated: Jul 6, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
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一个dermis-on-a-chip模型用于复合选.

Dhana Abdo1, Yimu Zhao2, Sargol Okhovatian3,4

  • 1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 27 King's College Circle, Toronto, ON, M5S 1A1, Canada.

Materials today. Bio
|July 31, 2025
PubMed
概括
此摘要是机器生成的。

一个新的dermis-on-a-chip模型在3D微组织中准确地复制皮肤纤维化 (痕). 这个平台有效地选抗纤维菌化合物,显示了改善伤口愈合疗法的前景.

关键词:
皮肤中的皮肤.纤维母细胞细胞是如何形成的纤维化 纤维化 纤维化器官在芯片上的器官这是一种类.

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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
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相关实验视频

Last Updated: Jul 6, 2026

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科学领域:

  • 生物医学工程 生物医学工程
  • 组织工程是组织工程.
  • 皮肤病学 皮肤病学

背景情况:

  • 皮肤纤维化阻碍伤口愈合,原因是肌纤维细胞过度激活和细胞外基质沉积.
  • 现有的体外模型,如单层培养和人体皮肤等效 (HSEs),对于药物查缺乏生理相关性和可扩展性.
  • 开发先进的模型对于了解纤维化和确定有效的抗纤维化疗法至关重要.

研究的目的:

  • 开发和验证一个dermis-on-a-chip平台,用于研究皮肤纤维化.
  • 评估平台在选抗纤维菌化合物的实用性.
  • 为了研究再生 (Q-) 对纤维化反应的影响.

主要方法:

  • 制造一个3D皮肤上芯片平台,容纳皮肤微组织.
  • 使用转化生长因子β (TGFβ) 诱导微组织中的纤维化特征.
  • 用Q治疗纤维化微组织,评估纤维化标志物.

主要成果:

  • TGFβ治疗诱导了关键的纤维化特征:完整性受损,拉力增加,细胞形态变化和亲纤维化细胞因子概况.
  • Q-可以选择性地减轻TGFβ诱导的纤维化变化.
  • Q-降低了拉力,抑制了光滑肌肉动蛋白 (SMA) 表达,并调节了细胞因子配置文件.

结论:

  • 芯片上的皮肤平台为研究皮肤纤维化提供了一个生理学上相关的模型.
  • 这种模型是有效的选抗纤维菌化合物和理解他们的机制.
  • 这些发现突出了Q-在调节纤维化过程中的潜力,以增强伤口修复.