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Updated: Sep 13, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
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Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

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工程化脂质纳米颗粒与协同树突细胞向和增强的内体逃生促进mRNA癌症疫苗的内体逃生

Sizhen Wang1, Jianyu Zheng1, Jiao Zhou1

  • 1National Key Laboratory of Immunity and Inflammation & School of Pharmacy, Naval Medical University, Shanghai, 200433, China.

Materials today. Bio
|July 31, 2025
PubMed
概括

这项研究为mRNA癌症疫苗引入了一种先进的脂质纳米粒子 (LNP). 这种新型LNP通过向输送和改善内体逃生来增强瘤特异性抗原表达,增强免疫反应.

关键词:
反瘤免疫学 抗瘤免疫学电流定位能力 - 定位能力.细胞内体逃脱是什么?脂质纳米颗粒是一种纳米粒子.mRNA疗法是一种mRNA疗法.

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