帕金森病患者的睡眠质量差:元分析和系统审查
Tong Leong Si1,2, Yue-Ying Wang2,3, Jia-Xin Li3
1Macao Observatory for Social Development, University of Saint Joseph, Macao, Macao SAR, China.
Frontiers in psychiatry
|July 31, 2025
概括
睡眠质量差影响了超过一半的帕金森病 (PD) 患者. 晚期发病的PD与睡眠不佳有关,这凸显了在PD管理中需要睡眠监测和卫生.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 睡眠质量差是帕金森病 (PD) 的普遍问题,报告的患病率在不同研究中存在显著差异.
- 了解整体患病率和促成因素对于有效的患者管理至关重要.
研究的目的:
- 确定帕金森病患者睡眠质量差的总体患病率.
- 确定导致不同研究中报告的流行率异质性的因素.
主要方法:
- 按照PRISMA和MOOSE的指导方针进行了系统的元分析,搜索主要数据库,直到2023年11月.
- 包括63个横截面或队列研究,包括9382名PD患者,使用随机效应模型评估患病率和异质性.
- 亚组和元回归分析探讨了诸如年龄,性别,心理健康,认知状态,疾病严重程度和药物等因素.
主要成果:
- 在9382名PD患者中,睡眠质量差的总体患病率为58.07% (95%CI:54.26-61.88%).
- 较高的患病率与来自欧洲和中亚,中高收入国家,混合患者来源,较低的诊断截止和运动障碍学会PD标准的研究有关.
- 超回归表明,晚期发病的PD与睡眠质量低下有显著的关联.
结论:
- 睡眠质量差是帕金森病的重要和常见的并发症.
- 在PD管理中,优先考虑定期监测睡眠质量和促进睡眠卫生是必不可少的.
- 需要在低收入和中等收入国家进行进一步的研究,以确保研究结果的全球适用性.
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