剖析植物提取物与人类肠道微生物群之间的分子相互作用
Leonardo Mancabelli1,2, Chiara Tarracchini3, Giulia Longhi3
1Department of Medicine and Surgery, University of Parma, Parma, Italy.
Frontiers in microbiology
|July 31, 2025
概括
植物性药物,如和英根,会影响人类的肠道微生物,改变它们的组成和功能. 这些植物化合物建立新的微生物相互作用,影响肠道微生物群.
科学领域:
- 微生物学 微生物学
- 人类微生物组 人类微生物组
- 生物活性化合物 生物活性化合物
背景情况:
- 人类的肠道微生物和人类有着长期的共生关系.
- 许多消费的植物和草药含有具有健康益处的生物活性化合物.
- 这些植物对肠道微生物群的组成和功能的影响仍然在很大程度上未知.
研究的目的:
- 研究植物对重建的人体肠道微生物群的分子影响.
- 了解植物在肠道微生物群中引起的分类学和功能变化.
- 在使用植物提取物时,评估肠道微生物之间的交叉养活动.
主要方法:
- 在体外生物反应器实验中使用重建的人体肠道微生物群.
- 进行元基因组和转录组分析以评估微生物变化.
- 培养特定的肠道微生物种群 (例如,Bacteroides spp.) 关于植物提取物.
主要成果:
- 植物产品诱导了肠道微生物群的显著分类学和功能变化.
- 在关键的肠道微生物成员中观察到交叉食相互作用.
- 植物的影响取决于存在的特定微生物种类.
结论:
- 植物对人类肠道微生物群产生分子影响.
- 在肠道微生物社区内建立了对植物物质的反应.
- 影响取决于环境,根据现有的微生物组成而有所不同.
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