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一个系统的基于证据的审查关于 miRNA 多态性在反复植入失败的循环检查

Bogdan Doroftei^1,2,3, Ovidiu-Dumitru Ilie¹, Ana-Maria Dabuleanu^1,2,3

¹Department of Mother and Child, Faculty of Medicine University of Medicine and Pharmacy "Grigore T. Popa" Iasi Romania.

Reproductive medicine and biology

|July 31, 2025

概括

微RNA (miRNA) 中特定的单核酸多态 (SNP) 与反复植入失败 (RIF) 有关. 一些miRNASNP和单种类型增加了RIF易感性,而另一些则提供了保护.

科学领域:

生殖医学生殖医学
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

复发性植入失败 (RIF) 是一个复杂的生殖挑战.
在RIF中,基因变异的作用,特别是微RNA (miRNA) 中的单核酸多态 (SNP),正在研究中.

研究的目的:

系统地审查和评估特定miRNASNP和RIF之间的关联.
为了识别miRNASNP和赋予RIF易感性或保护的哈普洛类型.

主要方法:

在主要的科学数据库 (PubMed-MEDLINE,科学网,Scopus,EMBASE) 进行了全面的文献搜索.
通过纽卡斯尔-太华量表 (NOS) 评估研究的质量.

主要成果:

几种miRNASNP和哈普洛型组合被确定为RIF的风险因素,包括miR-196a,miR-449b和miR-34a的特定基因型.
还确定了miRNASNP的保护组合,例如涉及miR-1302-3和miR-938的组合.
特定的miRNASNP与改变的凝血参数,激素水平 (FSH,TSH) 和功能标志物 (肌素,BUN) 相关.

结论:

特定的miRNASNP及其单种组合与RIF易感性或保护有显著的关联.
这些发现有助于了解RIF的遗传基础,并可能为未来的诊断或治疗策略提供信息.

关键词:

一个等位基因,一个等位基因.凝血是凝固的过程.基因型基因型基因型荷尔蒙性荷尔蒙性荷尔蒙性的在体外受精体外受精.这是一个微型RNA.经常发生的植入失败.脏脏的脏单个核酸的多态性.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...