癌症中的PI3K/AKT/mTOR轴:从发病到治疗
Mingyang Jiang1, Ke Zhang1, Zhenwang Zhang2
1Department of Bone and Joint Surgery The First Affiliated Hospital of Guangxi Medical University Nanning China.
MedComm
|July 31, 2025
概括
PI3K/AKT/mTOR通路在癌症中至关重要,它调节细胞生长和免疫反应. 了解其复杂的作用为改善癌症治疗和克服抗药性提供了新的精确瘤学策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞信号传递 细胞信号传递
背景情况:
- PI3K/AKT/mTOR信号轴控制细胞的基本过程,如增殖,新陈代谢和生存.
- 这种途径的失调是癌症发展,进展和对治疗的耐药性的关键驱动因素.
- 对PI3K/AKT/mTOR途径在癌症中的多面性作用的全面理解仍在发展.
研究的目的:
- 为PI3K/AKT/mTOR途径的瘤机制提供综合性审查.
- 探索其对关键细胞过程的调节及其在治疗耐药性中的作用.
- 评估针对精确瘤学这一途径的新兴治疗策略.
主要方法:
- 关于PI3K/AKT/mTOR途径在癌症生物学和治疗中的综合文献综述.
- 对瘤机制的分析,包括EMT,自,亡和代谢重编程.
- 评估非编码RNA的表观遗传调节以及该途径对治疗反应的影响.
主要成果:
- PI3K/AKT/mTOR通路控制瘤的特征,包括上皮细胞-介质细胞过渡,自,亡以及代谢转变 (糖解,铁亡,脂质代谢).
- 自起着双重作用,影响治疗耐药性和癌症动态.
- 表观遗传调节者 (miRNAs, lncRNAs, circRNAs) 和该途径与化疗,放射治疗和免疫治疗的相互作用是显著的.
- 该途径显著影响瘤微环境和治疗结果.
结论:
- PI3K/AKT/mTOR通路是瘤学中一个核心的治疗点.
- 针对这一轴为精密瘤学方法提供了潜在的潜力,以提高治疗效率和克服耐药性.
- 对综合策略的进一步研究对于改善癌症患者的治疗结果至关重要.
更多相关视频
07:38Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
272
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
18.1K
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
4.0K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
4.0K
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
Interactions Between Signaling Pathways
6.5K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.5K
The JAK-STAT Signaling Pathway
9.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.2K
Inhibition of Cdk Activity
4.9K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
