在结节性淋巴细胞的背景下出现的囊胞性肉瘤 主导的霍奇金淋巴瘤
Gul Emek Yuksek Wymer1, Susana Ferra1, Mohtashim Naeem1
1Department of Pathology and Laboratory Medicine, HCA Florida Healthcare, Plantation, Florida, USA.
Case reports in hematology
|July 31, 2025
概括
这项研究报告了一种罕见的囊性肉瘤病例,从结节性淋巴细胞主导的霍奇金淋巴瘤转变为. 这些发现强调了免疫类型和基因类型分析对于诊断二级囊细胞肉瘤的重要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 囊性肉瘤是一种罕见的,侵略性的瘤.
- 它可以主要由B细胞淋巴瘤引起或转变,包括慢性淋巴细胞白血病和卵泡淋巴瘤.
- 从B细胞淋巴瘤转变的二级囊细胞肉瘤非常罕见.
研究的目的:
- 要呈现出一种在结核性淋巴细胞主导性霍奇金淋巴瘤的背景下产生的囊性肉瘤的病例.
- 详细介绍这种罕见变化的形态和免疫表型特征.
- 为了解二次囊细胞肉瘤中共享的克隆起源作出贡献.
主要方法:
- 一名69岁的女性患者出现了广泛的淋巴腺病变.
- 诊断程序包括CT扫描和左下淋巴结切除.
- 免疫组织化学 (IHC) 染色在淋巴结活检上进行,以表征细胞群.
主要成果:
- 组织学检查显示淋巴结扩大,淋巴细胞和非典型的菌细胞混合透.
- IHC证实了非典型的B细胞对CD20,PAX5和BCL6呈阳性,非典型的囊细胞对CD68,CD163和S100呈阳性.
- 最终的诊断是在结核性淋巴细胞占主导地位的霍奇金淋巴瘤的背景下产生的囊性肉瘤.
结论:
- 这一案例说明了一种罕见的囊细胞肉瘤从结节性淋巴细胞占主导地位的霍奇金淋巴瘤转变的例子.
- 形态学,免疫类型和基因类型分析对于诊断这种转变至关重要.
- 根据有限的病例报告,B细胞淋巴瘤和囊性肉瘤之间的共享克隆起源被认为是B细胞淋巴瘤和囊性肉瘤.
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