性别确认激素治疗和成人功能变化:一项基于人口的回顾性研究
Silvia J Leon1, Thomas W Ferguson1,2, Reid Whitlock1
1Chronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba, Canada.
Kidney medicine
|July 31, 2025
概括
性别确认激素治疗 (GAHT) 可能会增加跨性别女性的血清肌素. 这项研究发现,在跨性别和性别多样性成年人中,高血压治疗没有增加病或高血压的风险.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 性别确认激素疗法 (GAHT) 影响身体组成,但其对功能的影响尚不清楚.
- 了解GAHT对脏的影响对于变性人和性别多样性 (TGD) 个体的健康至关重要.
研究的目的:
- 为了研究GAHT和TGD成年人的功能之间的关联.
- 评估血清肌素的变化,尿中的白蛋白与肌素的比率,以及急性损伤,慢性病和高血压的风险.
主要方法:
- 使用加拿大曼尼托巴省 (2007-2018) 的卫生行政数据进行的回顾性观察队列研究.
- 接受GAHT的TGD成年人与未接受GAHT的成年人进行比较,按出生时分配的性别分层 (AFAB和AMAB).
- 使用多变量回归和Cox比例危险模型来评估处方后2年后的结果.
主要成果:
- 在接受GAHT的出生时被分配为女性 (AFAB) 的个体中,与没有GAHT的个体相比,18个月和21个月的血清肌素水平呈现出统计学上显著的增加.
- 在接受GAHT的出生时被分配为男性 (AMAB) 个体中,没有观察到肌素变化的显著差异.
- 在AFAB或AMAB个体中,启动GAHT与发生慢性病或高血压的风险增加无关.
结论:
- 在AFAB个体中,GAHT与血清肌素水平升高有关.
- 需要进一步的研究,以充分阐明GAHT对TGD群体功能的长期影响.
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