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相关概念视频

Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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IR Frequency Region: Fingerprint Region01:03

IR Frequency Region: Fingerprint Region

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IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
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IR Spectrum01:19

IR Spectrum

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When infrared (IR) radiation passes through a molecule, the bonds stretch or bend by absorbing the radiation. This absorption creates the molecule's absorption spectrum, which is the plot of its percentage transmittance versus wavenumber.
Transmittance is defined as the ratio of the radiant power passing through a sample to that from the radiation's source. Multiplying the transmittance by 100 gives the percent transmittance (%T), which varies between 100% (no absorption) and 0%...
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IR Frequency Region: X–H Stretching01:24

IR Frequency Region: X–H Stretching

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In IR spectroscopy, signals produced by the X−H bonds (such as C−H, O−H, or N−H) can be observed in the frequency range of  2700–4000 cm–1. The C−H stretching vibration forms sharp bands in the region 2850–3000 cm–1. The presence of the O−H stretching vibration leads to the forming of an absorption band in the frequency range 3650–3200 cm−1. At the same time, N−H stretching can be confirmed by absorption bands in...
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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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相关实验视频

Updated: Sep 13, 2025

Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS
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虹膜文件扩展名 虹膜文件扩展名

Ryan Erik Landvater1, Michael David Olp1, Mustafa Yousif1

  • 1University of Michigan Medical School, Department of Pathology, 2800 Plymouth Road, Ann Arbor 48109-2800, MI, USA.

Journal of pathology informatics
|July 31, 2025
PubMed
概括
此摘要是机器生成的。

一个新的Iris文件扩展为高效的实时图像传输和显示提供了一个无关供应商的数字病理学格式. 这个格式满足了整个幻灯片成像观看系统的性能需求.

关键词:
迪科姆公司 (DICOM)数字病理学数字病理学文件格式 文件格式文件规格 文件规格 文件规格虹膜 虹膜 虹膜 虹膜性能数字病理学 性能数字病理学整个幻灯片图像的图像.

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Last Updated: Sep 13, 2025

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科学领域:

  • 数字病理学数字病理学
  • 医疗成像医学成像
  • 计算机科学 计算机科学

背景情况:

  • 数字病理学的采用需要高效的数据格式,以便实时传输和显示.
  • 针对放射学设计的DICOM等现有标准无法满足全幻灯片成像 (WSI) 的特定性能要求.
  • 对于优化用于数字病理学工作流程中的性能的供应商无关的二进制幻灯片格式有着未满足的需求.

研究的目的:

  • 介绍Iris文件扩展,一个新的二进制容器规范.
  • 设计虹膜以优化整个幻灯片图像 (WSI) 观看系统的性能.
  • 为高效的数字病理学数据处理提供开源解决方案.

主要方法:

  • 开发了一个二进制容器规范 (Iris文件扩展),专注于性能.
  • 整合了现代压缩,动态结构,可选元数据和验证功能.
  • 创建了用于 (非) 序列化和验证的源代码,支持C ++,Python和JavaScript.
  • 发布的开源编码器/解码器实现和语言绑定.

主要成果:

  • 定义了Iris文件扩展规范,强调了WSI观看器的性能.
  • 该规范包括压缩,动态结构,可选元数据,验证和恢复等功能.
  • 对Iris的开源工具和库可用C++,Python和JavaScript. 在C++,Python和JavaScript中提供.
  • 虹膜规范是在创意共享许可证下发布的.

结论:

  • 虹膜文件扩展为数字病理学提供了一个高性能,无需供应商的解决方案.
  • 它解决了现有格式对实时WSI显示和传输的限制.
  • 开源的可用性有助于整合到现有的数字病理学解决方案中.