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Updated: Sep 13, 2025

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

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整合性空间和单细胞转录学阐明了肝细胞癌中的被编程细胞死亡驱动的瘤微环境动态

Kai Lei1,2, Yutong Zhao3, Shumin Li3

  • 1Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Frontiers in immunology
|July 31, 2025
PubMed
概括

这项研究开发了一种编程细胞死亡 (PCD) 预测模型,用于肝细胞癌 (HCC) 的预后. 该模型识别出不同的瘤微环境和免疫细胞疲劳,帮助个性化HCC治疗策略.

关键词:
在Ube2E1E1中使用.肝细胞癌是肝细胞癌.预测模型 预测模型被编程的细胞死亡.瘤微环境是一个微环境.

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Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma08:25

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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