在接受内镜性粘膜切除的患者中,肠道微生物特征和食纤维干预
Wen-Cui Niu1, Shao-Hua Wang2, Ye Zhao3
1Department of Nutrition, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China.
World journal of gastrointestinal surgery
|July 31, 2025
概括
食纤维干预有助于在内镜性粘膜切除 (EMR) 后肠道微生物群的恢复. 这种方法改善了肠道健康,并为EMR患者提供了新的康复策略.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 内镜粘膜切除 (EMR) 是早期消化道瘤的关键最小侵入性治疗方法.
- 肠道微生物群在疾病发展中发挥着关键作用,但其在EMR后的变化尚未完全理解.
- 食纤维对EMR后微生物群恢复的影响需要进一步调查.
研究的目的:
- 研究食纤维干预对接受EMR的患者肠道微生物群恢复的影响.
- 评估食纤维在改善术后结果和恢复肠道微生态平衡方面的潜力.
主要方法:
- 在2020年至2023年期间接受EMR的86名患者的回顾性分析.
- 饮食纤维干预组与常规随访组的比较.
- 高通量16S rRNA基因测序用于分析微生物群的多样性,结构和功能.
主要成果:
- 经过EMR手术,肠道微生物群的多样性显著下降.
- 饮食纤维组显示出更高的微生物群恢复率和多样性指数 (P < 0.05).
- 乳球菌和双菌的丰富度增加,干预组中肠道屏障功能基因的高调节.
结论:
- 食纤维干预有效促进肠道微生物群在EMR后的恢复.
- 这种干预改善了肠道微生态平衡.
- 食纤维为EMR患者的临床康复提供了一个新的策略.
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