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相关概念视频

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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胃肠道恶性瘤的多学科前景:系统性审查

Thai-Hau Koo1, Yi-Lin Lee2, Xue-Bin Leong2

  • 1Department of Internal Medicine, University Sains Malaysia Specialist Hospital, Kubang Kerian 16150, Kelantan, Malaysia.

World journal of gastrointestinal surgery
|July 31, 2025
PubMed
概括

多omics方法显著改善了胃肠道癌的早期检测和个性化治疗. 将基因组,蛋白质组和微生物组数据与人工智能集成,可以提高诊断准确度和治疗策略,以获得更好的患者结果.

关键词:
发现生物标志物的发现.胃肠道的恶性瘤.多个omics的多个omics.精确瘤学是一门精确的专业.蛋白质基的蛋白质基体是什么治疗耐药性是一种治疗性耐药性.

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科学领域:

  • 在瘤学瘤学.
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 胃肠道 (GI) 恶性瘤是全球癌症死亡的主要原因.
  • 对胃肠道癌的早期检测和个性化治疗仍然是临床挑战.
  • 多omics方法为肠胃癌的精密瘤学提供了先进的工具.

研究的目的:

  • 调查多omics在胃肠道癌早期检测,风险分层和治疗优化中的应用.
  • 在肠道恶性瘤中探索多种omics用于生物标志物发现.
  • 审查针对个性化瘤学的多学科数据的整合.

主要方法:

  • 按照PRISMA 2020指南进行系统审查.
  • 在五个数据库 (PubMed,ScienceDirect,Scopus,ProQuest,Web of Science) 搜索了2015年以后的研究.
  • 包括在肠道癌症,人工智能和有机体建模中对多omics集成的人类受试者研究.

主要成果:

  • 多omics平台在早期检测胃肠道癌症方面表现优于传统生物标志物.
  • 识别了循环瘤DNA,细胞外囊泡和人工智能算法,以加强诊断.
  • 揭示了对免疫调节,瘤微环境,转移和耐药性的见解.

结论:

  • 多omics方法显著提前早期诊断和个性化治疗胃肠道恶性瘤.
  • 与人工智能,有机体模型和微生物群概况的整合推动了精确瘤学.
  • 多主题数据有助于改善预后评估和治疗策略.