在患有初级和二级空的患者中,垂体功能
Lucas Steckel1, Elke R Gizewski2,3, Susanne Kaser1
1Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
Frontiers in endocrinology
|July 31, 2025
概括
空塞拉 (ES) 诊断正在增加. 激素缺陷很常见,特别是在二级ES中,但在诊断时下垂体功能正常的患者中,新缺陷的风险很低,这表明不需要例行随访.
科学领域:
- 内分泌学 在内分泌学.
- 神经辐射学神经辐射学
- 临床医学 临床医学
背景情况:
- 由于神经放射学成像技术的进步,空 (ES) 的偶然发现正在增加.
- 偶然发现空骨的临床意义尚不清楚.
- 这项研究调查了空的临床相关性和荷尔蒙后果.
研究的目的:
- 评估新诊断的初级或二级空腹患者中激素缺乏症的发生率和临床相关性.
- 为了确定在诊断时脑下垂体功能完好无损的患者中发展低垂体症的风险.
- 评估空塞拉患者常规随访的需要.
主要方法:
- 一项纵向的单中心研究分析了首次诊断为初级或二级空 sella 的患者.
- 患者进行了长达五年的随访.
- 通过基底激素水平和动态刺激测试来诊断激素缺乏症.
主要成果:
- 包括119名患者 (97名初级ES,22名二级ES) 在内.
- 在基线时,34%的初级ES患者和63.6%的二级ES患者患有垂体缺陷.
- 初级ES (25.8%) 中最常见的是阴性腺症,而二级ES (54.5%) 中最常见的是上腺功能不足.
结论:
- 荷尔蒙缺乏症在空塞拉中普遍存在,二次ES和男性患者的风险更高.
- 在最初具有正常 pituitary 功能的患者中,患上 hypopituitarism 的风险很低.
- 对于有完整 pituitary 功能的空塞拉患者进行常规后续评估是不合理的.
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