肥胖是早期结直肠癌的危险因素:来自全国代表性数据库的证据
Omar Khattab1, Mohamed Alharami2,3, Frhaan Zahrawi4
1Department of Internal Medicine, Kettering Health Network, Kettering, OH 45429, United States. omar.khattab@ketteringhealth.org.
World journal of clinical oncology
|July 31, 2025
概括
身体圆度指数 (BRI) 是早期结直肠癌 (eoCRC) 风险的更强有力的预测指标,而不是BMI或腰围. 这一发现对于识别CRC风险较高的年轻人至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 早发性CRC (eoCRC) 发病率正在上升,其潜在驱动因素尚不清楚.
- 已经确定的危险因素,如肥胖和吸烟,需要进一步调查它们在eocrc中的作用.
研究的目的:
- 检查各种风险因素对eocrc的影响.
- 特别关注肥胖及其相关参数在eocrc中的作用.
主要方法:
- 国家健康和营养检查调查数据 (1999-2023) 的横截面分析.
- 包括30321名年龄在18-49岁之间的美国成年人.
- 评估人口统计,生活方式和人体统计数据 (BMI,BRI,WC);使用后勤回归和倾向得分匹配.
主要成果:
- 48名参与者被诊断患有eocrc.
- eoCRC患者年龄较大,腰围 (WC) 和身体圆度指数 (BRI) 更高.
- BRI是eoCRC最强的独立预测因素,较高的四分位数与比率增加10倍以上有关;在完全调整的模型中,BMI和WC没有显著意义.
结论:
- 与其他肥胖指数相比,身体圆度指数 (BRI) 是eoCRC风险的优越预测指标.
- BRI可以有效地识别患结肠直肠癌风险较高的年轻人.
相关概念视频
Obesity
620
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
620
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Bulimia Nervosa
195
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
195
Bias in Epidemiological Studies
687
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
687
Cancer Survival Analysis
456
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
456
Prevalence and Incidence
818
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
818


